On the interaction of a single-photon wave packet with an excited atom

The interaction of a single-photon wave packet with an initially excited two-level atom in free space is studied in semiclassical and quantum approaches. It is shown that the final state of the field does not contain doubly occupied modes. The process of the atom's transition to the ground state may be accelerated, decelerated or even reversed by the incoming photon, depending on parameters. The spectrum of emitted radiation is close to the sum of the spectrum of the incoming single-photon wave packet and the natural line shape, with small and complicated deviations.Comment: 17 pages, 5 figure

The effect of femoral component rotation on the five-year outcome of cemented mobile bearing total knee arthroplasty.

PURPOSE: Performing total knee replacement, accurate alignment and neutral rotation of the femoral component are widely believed to be crucial for the ultimate success. Contrary to absolute bone referenced alignment, using a ligament balancing technique does not automatically rotate the femoral component parallel to the transepicondylar axis. In this context we established the hypothesis that rotational alignment of the femoral component parallel to the transepicondylar axis (0° ± 3°) results in better outcome than alignment outside of this range. METHODS: We analysed 204 primary cemented mobile bearing total knee replacements five years postoperatively. Femoral component rotation was measured on axial radiographs using the condylar twist angle (CTA). Knee society score, range of motion as well as subjective rating documented outcome. RESULTS: In 96 knees the femoral component rotation was within the range 0 ± 3° (neutral rotation group), and in 108 knees the five-year postoperative rotational alignment of the femoral component was outside of this range (outlier group). Postoperative CTA showed a mean of 2.8° (±3.4°) internal rotation (IR) with a range between 6° external rotation (ER) and 15° IR (CI 95). No difference with regard to subjective and objective outcome could be detected. CONCLUSION: The present work shows that there is a large given natural variability in optimal rotational orientation, in this study between 6° ER and 15° IR, with numerous co-factors determining correct positioning of the femoral component. Further studies substantiating pre- and postoperative determinants are required to complete the understanding of resulting biomechanics in primary TKA

Ponderomotive entangling of atomic motions

We propose the use of ponderomotive forces to entangle the motions of different atoms. Two situations are analyzed: one where the atoms belong to the same optical cavity and interact with the same radiation field mode; the other where each atom is placed in own optical cavity and the output field of one cavity enters the other.Comment: Revtex file, five pages, two eps figure

Deorbit kit demonstration mission

In Low Earth Orbit, it is possible to use the ambient plasma and the geomagnetic field to exchange momentum with the Earth's magnetosphere without using propellant. A device that allows an efficient momentum exchange is the electrodynamic tether (EDT), a long conductor attached to the satellite. EDT technology has been demonstrated in several past missions, being the Plasma Motor Generator mission (NASA 1993) one of the most successful. Nevertheless, it is not until today that reality has imposed a strong need and a concrete use case for developing this technology. In March 2019, the European Commission project Electrodynamic Tether technology for PAssive Consumable-less deorbit Kit (E.T.PACK) started the design of a new generation EDT. After completing the design phase, the consortium manufactured and is currently testing a Deorbit Kit Demonstrator (DKD) breadboard based on EDT technology. The objective of E.T.PACK is to reach Technology Readiness Level equal to 4 by 2022. The DKD is a standalone 24-kg satellite with the objective to demonstrate the performances of the improved EDT solution and validate its ultra-compact deployment system. The DKD is composed of two modules that will separate in orbit extending a 500-m long tape-like tether. The deployed bare-Aluminium tether will capture electrons from the ambient plasma passively and the circuit will be closed with the ionospheric plasma by using an active electron emitter. E.T.PACK tether will take advantage of several novelties with respect to the mission flown in the past that will allow to optimize the system volume and mass. Once successful demonstrated in orbit, the team plans to develop a suite of EDT systems capable of deorbiting satellites between 200 and 1000 kg from an altitude up to 1200 km in a few months. The work presents the current design status of the de-orbit kit demonstrator breadboard, the simulations of the system deorbit performances and the development approach.This work was supported by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No.828902 (3M€ E.T.PACK project) and No.101034874 (100K€ BMOM project). SG is supported by an Industrial Ph.D funded by Comunidad de Madrid (135K€ IND2019/TIC17198). The team has recently got 2.5M€ additional financial support from European Union (ETPACK-F project No. 101058166) for the manufacturing and qualification of the In Orbit Demonstration (IOD) by the end of 2025

Ultrathin 2 nm gold as ideal impedance-matched absorber for infrared light

Thermal detectors are a cornerstone of infrared (IR) and terahertz (THz) technology due to their broad spectral range. These detectors call for suitable broad spectral absorbers with minimalthermal mass. Often this is realized by plasmonic absorbers, which ensure a high absorptivity butonly for a narrow spectral band. Alternativly, a common approach is based on impedance-matching the sheet resistance of a thin metallic film to half the free-space impedance. Thereby, it is possible to achieve a wavelength-independent absorptivity of up to 50 %, depending on the dielectric properties of the underlying substrate. However, existing absorber films typicallyrequire a thickness of the order of tens of nanometers, such as titanium nitride (14 nm), whichcan significantly deteriorate the response of a thermal transducers. Here, we present the application of ultrathin gold (2 nm) on top of a 1.2 nm copper oxide seed layer as an effective IR absorber. An almost wavelength-independent and long-time stable absorptivity of 47(3) %, ranging from 2 $\mu$m to 20 $\mu$m, could be obtained and is further discussed. The presented gold thin-film represents analmost ideal impedance-matched IR absorber that allows a significant improvement of state-of-the-art thermal detector technology

Engineering two-mode interactions in ion traps

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Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagic as well as lysosomal deficiencies. Because CTSD (cathepsin D) has been proposed to be the major lysosomal protease involved in SNCA degradation, its deficiency has been linked to the presence of insoluble SNCA conformers in the brain of mice and humans as well as to the transcellular transmission of SNCA aggregates. We here postulate that SNCA degradation can be enhanced by the application of the recombinant human proform of CTSD (rHsCTSD). Our results reveal that rHsCTSD is efficiently endocytosed by neuronal cells, correctly targeted to lysosomes and matured to an enzymatically active protease. In dopaminergic neurons derived from induced pluripotent stem cells (iPSC) of PD patients harboring the A53T mutation within the SNCA gene, we confirm the reduction of insoluble SNCA after treatment with rHsCTSD. Moreover, we demonstrate a decrease of pathological SNCA conformers in the brain and within primary neurons of a CTSD-deficient mouse model after dosing with rHsCTSD. Boosting lysosomal CTSD activity not only enhanced SNCA clearance, but also restored endo-lysosome and autophagy function in human and murine neurons as well as tissue. Our findings indicate that CTSD is critical for SNCA clearance and function. Thus, enzyme replacement strategies utilizing CTSD may also be of therapeutic interest for the treatment of PD and other synucleinopathies aiming to decrease the SNCA burden.authorsversionepub_ahead_of_prin

A multicentre matched case control study of risk factors for Preeclampsia in healthy women in Pakistan

<p>Abstract</p> <p>Background</p> <p>Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality world-wide. The risk for developing preeclampsia varies depending on the underlying mechanism. Because the disorder is heterogeneous, the pathogenesis can differ in women with various risk factors. Understanding these mechanisms of disease responsible for preeclampsia as well as risk assessment is still a major challenge. The aim of this study was to determine the risk factors associated with preeclampsia, in healthy women in maternity hospitals of Karachi and Rawalpindi.</p> <p>Methods</p> <p>We conducted a hospital based matched case-control study to assess the factors associated with preeclampsia in Karachi and Rawalpindi, from January 2006 to December 2007. 131 hospital-reported cases of PE and 262 controls without history of preeclampsia were enrolled within 3 days of delivery. Cases and controls were matched on the hospital, day of delivery and parity. Potential risk factors for preeclampsia were ascertained during in-person postpartum interviews using a structured questionnaire and by medical record abstraction. Conditional logistic regression was used to estimate matched odds ratios (ORs) and 95% confidence intervals (95% CIs).</p> <p>Results</p> <p>In multivariate analysis, women having a family history of hypertension (adjusted OR 2.06, 95% CI; 1.27-3.35), gestational diabetes (adjusted OR 6.57, 95% CI; 1.94 -22.25), pre-gestational diabetes (adjusted OR 7.36, 95% CI; 1.37-33.66) and mental stress during pregnancy (adjusted OR 1.32; 95% CI; 1.19-1.46, for each 5 unit increase in Perceived stress scale score) were at increased risk of preeclampsia. However, high body mass index, maternal age, urinary tract infection, use of condoms prior to index pregnancy and sociodemographic factors were not associated with higher risk of having preeclampsia.</p> <p>Conclusions</p> <p>Development of preeclampsia was associated with gestational diabetes, pregestational diabetes, family history of hypertension and mental stress during pregnancy. These factors can be used as a screening tool for preeclampsia prediction. Identification of the above mentioned predictors would enhance the ability to diagnose and monitor women likely to develop preeclampsia before the onset of disease for timely interventions and better maternal and fetal outcomes.</p

Preparation of nonclassical states in cavities with a moving mirror

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